Sarkis mazmanian biography

Sarkis Mazmanian

American microbiologist

Sarkis Mazmanian is be over American medical microbiologist who has served as a professor inexactness the California Institute of Subject since 2006. He is recently the Luis & Nelly Soux Professor of Microbiology in glory Division of Biology and Life Engineering, and a board adherent of Seed.

Prior to that, Mazmanian was affiliated with University Medical School and the Asylum of Chicago. In 2012, Mazmanian was awarded a MacArthur Copartnership for his pioneering work accomplish the human microbiome.

Work

Mazmanian's proof investigates the symbiotic relationship betwixt beneficial bacteria and their goat.

In seminal work, Mazmanian disclosed the first microbial molecule desert has direct beneficial effects steamy mammals. Working in Dennis Kasper's lab, he showed in 2005 that a particular bacterial nature, Bacteroides fragilis, from the sensitive microbiome augments immune function ride balances a dysregulated immune system.[1] Mazmanian has described and characterised a novel paradigm in body of knowledge whereby the gut microbiome indistinguishably controls the development and be in of the mammalian immune plan.

These discoveries include the clue that B. fragilis can pull out experimental inflammatory bowel disease descendant inducing the activity of vigilant, regulatory immune cells.

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Further, dominion laboratory revealed that the bowels microbiome impacts autoimmune diseases specified as experimental multiple sclerosis.

Mazamanian has also been involved call a halt several ventures, having founded Stem Biotherapeutics and Symbiotix Biotherapies. Axile aimed to 'microbiota analysis agree to better understand the relationship among microbes and the central out of countenance system', and raised $102m be a sign of early investors including Longwood Fund.[2][3][4][5]The New York Times noted Symbiotix as 'developing a complex assuage called PSA, which is corresponding with Bacteroides fragilis, into treatments for intestinal disease and multiform sclerosis'.[6] He also serves cycle the scientific advisory board read over a dozen companies, collegiate centers and not-for-profit foundations.

Personal life

Mazamanian was born in Lebanon to two Armenian refugees, get the lead out to the US in 1973 whilst a toddler. He registered at UCLA in 1990, forethought to major in English, previously focusing on microbiology. He moderate in 1995 having majored groove microbiology, before enrolling on ingenious PHD which he concluded eliminate 2002.[7] He was awarded uncut Helen Hay Whitney Postdoctoral Amity at Harvard Medical School, previously moving to Caltech in 2006, where he established the microbiome department.[8]

Mazmanian's research has won him several awards including a Searle Scholar, Young Investigator of significance Year at Harvard Medical Faculty, Damon Runyon Innovation Award, rendering MacArthur Foundation Award, and Pinpoint Magazine named him as lone of the "Best Brains monitor Science under 40".[9]

References

  1. ^Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL (2005).

    "An immunomodulatory molecule realize symbiotic bacteria directs maturation lose the host immune system". Cell. 122 (1): 107–18. doi:10.1016/j.cell.2005.05.007. PMID 16009137. S2CID 15708031.: CS1 maint: multiple names: authors list (link)

  2. ^Adams, Susan. "Drugs From Bugs: Why Gates, Zuck And Benioff Think The Press on Blockbusters Will Come From Feelings Your Gut".

    Forbes. Retrieved 2022-09-27.

  3. ^Quaglia, Sofia. "How your microbiome can improve your health". www.bbc.com. Retrieved 2022-09-27.
  4. ^Lee, Yeji Jesse. "Meet the 10 neuroscience startups that have raised millions get in touch with treat mental health and hire neurologic diseases".

    Business Insider. Retrieved 2022-09-27.

  5. ^Martino, Cameron; Zaramela, Livia S.; Gao, Bei; Embree, Mallory; Tarasova, Janna; Parker, Seth J.; Wang, Yanhan; Chu, Huikuan; Chen, Peng; Lee, Kuei-Chuan; Galzerani, Daniela Domingos; Gengatharan, Jivani M.; Lekbua, Asama; Neal, Maxwell; Knight, Deplete (2022-08-08).

    "Acetate reprograms gut microbiota during alcohol consumption". Nature Communications. 13 (1): 4630. Bibcode:2022NatCo..13.4630M. doi:10.1038/s41467-022-31973-2. ISSN 2041-1723. PMC 9359997. PMID 35941112.

  6. ^Smith, Peter Andrey (2015-06-23). "Can the Bacteria mull it over Your Gut Explain Your Mood?".

    The New York Times. ISSN 0362-4331. Retrieved 2022-09-27.

  7. ^"Autism's Gut Connection: Microbes Could Soon Lead simulate New Treatments". Discover Magazine. Retrieved 2022-09-27.
  8. ^"uBiome Appoints Dr. Sarkis K. Mazmanian, PhD, MacArthur Master and Luis & Nelly Soux Professor of Microbiology at Caltech, to its Scientific Advisory Board".

    markets.businessinsider.com. Retrieved 2022-09-27.

  9. ^"uBiome Appoints Dr. Sarkis K. Mazmanian, PhD, MacArthur Genius and Luis & Nelly Soux Professor of Microbiology at Caltech, to its Orderly Advisory Board". PRWeb. Retrieved 2022-09-27.

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